Blood biomarkers and measures of pulmonary function–A study from the Swedish twin registry - 04/08/12
, Claes Lindberg a , Maria Gerhardsson de Verdier a , Ulf Nihlén a, c , Martin Anderson d , Magnus Svartengren e , Kristina Forsman-Semb a, f 
Corresponding author. AstraZeneca R&D, 43183 Mölndal, Sweden. Tel.: +46 31 3566094.Summary |
Objective |
There is great need of biomarkers for research and clinical purposes in COPD. This study explored the relationships between ten putative plasma biomarkers of COPD and physiological measures of reduced lung function.
Methods |
FEV1, FVC, residual volume/total lung capacity (RV/TLC) and CO diffusion capacity (DLCO) were assessed in 357 subjects from the Swedish Twin Registry. The lung function measures were studied in relation to plasma levels of desmosines, C-reactive protein (CRP), plasminogen inhibitor activator (PAI-1) concentration and activity, tissue inhibitor of metalloproteinase (TIMP-1), clara cell protein 16 (CC16), surfactant protein D (SPD), matrix metalloproteinase 9 (MMP-9), hepatocyte growth factor (HGF) and interleukin (IL)-8.
Results |
After adjustments for age, sex, height, BMI and smoking, FEV1 was significantly associated with PAI-1 activity and desmosines. RV/TLC was significantly associated with CC16, PAI-1 concentration and PAI-1 activity, and DLCO was significantly associated with desmosines, TIMP-1 and CRP. When the multivariate analysis was restricted to subjects with COPD (i.e., FEV1/FVC < 0.70), CRP and desmosines were inversely associated with lung function.
Conclusion |
Several biomarkers were associated with lung function in this cross-sectional study. Especially CRP and desmosines could be useful markers to assess disease severity in subjects with COPD.
Le texte complet de cet article est disponible en PDF.Keywords : COPD, Biomarkers, Inflammation, Lung function
Plan
Vol 106 - N° 9
P. 1250-1257 - septembre 2012 Retour au numéro
Article précédent
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