In this article, tissue and bronchoalveolar lavage biomarkers of asthma are evaluated for their use in asthma and evaluated in the context of the phenotype that they may best represent. It is hoped that studies that better link biomarkers to specific phenotypes will eventually improve the ability to evaluate genetic features, diagnose, measure progression, and tailor treatments. Although some biomarkers may only be associated with disease, it is also likely that some may be mechanistically involved. Some of these biomarkers may then also become targets for specific treatment.