Diarrhea Caused By Carbohydrate Malabsorption - 21/08/12

Doi : 10.1016/j.gtc.2012.06.003

Heinz F. Hammer, MD ^a,^b,^⁎ , Johann Hammer, MD ^c
^a Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, Graz 8036, Austria
^b Privatklinik Kastanienhof, Gritzenweg 16, Graz 8052, Austria
^c Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Vienna, Währinger Gürtel 18–20, Vienna 1090, Austria

Corresponding author. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, Graz 8036, Austria.

Résumé

This article will focus on the role of the colon in the pathogenesis of diarrhea in carbohydrate malabsorption or physiologically incomplete absorption of carbohydrates, and on the most common manifestation of carbohydrate malabsorption, lactose malabsorption. In addition, incomplete fructose absorption, the role of carbohydrate malabsorption in other malabsorptive diseases, and congenital defects that lead to malabsorption will be covered. The article concludes with a section on diagnostic tools to evaluate carbohydrate malabsorption.

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Keywords : Lactose, Fructose, Antibiotics, Colonic transit, Dietary fiber, Intestinal gas

Plan

Introduction

Methods for establishing the role of carbohydrate malabsorption for the pathogenesis of diarrhea

The role of the colon for colonic salvage of malabsorbed or incompletely absorbed carbohydrates and gas production

Influence of antibiotics on colonic carbohydrate salvage

The role of colonic transit in carbohydrate-induced diarrhea

Diarrhea in carbohydrate malabsorption—multiple influencing factors

Carbohydrate malabsorption in malabsorptive diseases: innocent bystander or relevant for calorie loss and diarrhea?

Does carbohydrate malabsorption contribute to fecal energy loss in Roux-en-Y gastric bypass?

Lactase deficiency and lactose malabsorption

Incomplete absorption and intolerance of fructose (fructose malabsorption)

Disaccharidase deficiencies and transport defects for monosaccharides

Diagnosis of carbohydrate malabsorption

Summary

	The authors have nothing to disclose.
	This work was supported by research grants P 18101-B09 and L309-B09 from the Austrian Science Fund (FWF, Fonds zur Förderung der wissenschaftlichen Forschung) to Dr J. Hammer.