Detection on Dynamic Changes of Endothelial Cell Specific Molecule–1 in Acute Rejection After Renal Transplantation - 25/08/12
, Liang Wang a, Chao Wang b, Qingtang Wang a, Hang Yang a, Ping Liang a, Fengshuo Jin c
Reprint requests: Shadan Li, M.D., Department of Urology, General Hospital of Chengdu Military Command, Chengdu 610083, ChinaRésumé |
Objective |
To investigate the value of dynamic monitoring of endothelial cell specific molecule–1 (ESM-1) in diagnosing acute rejection after renal transplantation.
Methods |
ESM-1 expression was observed in peripheral blood circulating endothelial cells and renal allografts after renal transplantation, and was compared to the flow cytometry (FCM) results of urine HLA-DR+ lymphocytes.
Results |
In patients with acute rejection, ESM-1 mRNA and protein expression increased significantly (P < .01). Real-time polymerase chain reaction detection of ESM-1 mRNA in peripheral blood cells was more sensitive and specific than FCM detection of urine HLA-DR+ lymphocytes. Moreover, real-time PCR detection is characterized by convenient sampling and good reproducibility.
Conclusion |
ESM-1 is a new marker for endothelial cell activation. However, its significance during acute rejection in renal transplantation is still unclear. Our study demonstrates that ESM-1 may reflect the degree of endothelial cell injury in renal allografts, and that it may serve as a highly sensitive and specific marker for acute rejection after renal transplantation.
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| Shadan Li and Liang Wang contributed equally to this article. |
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| Financial Disclosure: The authors declare that they have no relevant financial interests. |
Vol 80 - N° 3
P. 738.e1-738.e8 - septembre 2012 Retour au numéro
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