Cerebrospinal Fluid Reference Ranges in Term and Preterm Infants in the Neonatal Intensive Care Unit - 22/09/12
, Samir S. Shah, MD, MSCE 2, Michael A. Padula, MD 1, Soraya Abbasi, MD 3, Karin L. McGowan, PhD 4, Mary C. Harris, MD 1
Reprint requests: Lakshmi Srinivasan, The Children’s Hospital of Philadelphia, Room 2424, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104.Abstract |
Objective |
To determine reference ranges of cerebrospinal fluid (CSF) laboratory findings in term and preterm infants in the neonatal intensive care unit.
Study design |
Data were collected prospectively as part of a multisite study of infants aged <6 months undergoing lumbar puncture for evaluation of suspected sepsis. Infants with a red blood cell count >500 cells/μL or a known cause of CSF pleocytosis were excluded from the analysis.
Results |
A total of 318 infants met the inclusion criteria. Of these, 148 infants (47%) were preterm, and 229 (72%) received antibiotics before undergoing lumbar puncture. The upper reference limit of the CSF white blood cell (WBC) count was 12 cells/μL in preterm infants and 14 cells/μL in term infants. CSF protein levels were significantly higher in preterm infants (upper reference limit, 209 mg/dL vs 159 mg/dL in term infants; P < .001), and declined with advancing postnatal age in both groups (preterm, P = .008; term, P < .001). CSF glucose levels did not differ in term and preterm infants. Antibiotic exposure did not significantly affect CSF WBC, protein, or glucose values.
Conclusions |
CSF WBC counts are not significantly different in preterm and term infants. CSF protein levels are higher and decline more slowly with postnatal age in preterm infants compared with term infants. This study provides CSF reference ranges for hospitalized preterm and term infants, particularly in the first month of life.
Le texte complet de cet article est disponible en PDF.Keyword : CSF, IVH, LP, NICU, RBC, WBC
Plan
| Supported by the Clinical and Translational Research Center (grant UL1-RR-024134). M.H. received support from the University Research Foundation and a Foerderer Murray Award. S.S. received support from the Robert Wood Johnson Foundation’s Physician Faculty Scholar Program. The content of this article is solely the responsibility of the authors and does not represent the official views of the aforementioned funding agencies. The authors declare no conflicts of interest. |
Vol 161 - N° 4
P. 729-734 - octobre 2012 Retour au numéro
Article précédent
- Natural History of Pediatric Intestinal Failure: Initial Report from the Pediatric Intestinal Failure Consortium
- Robert H. Squires, Christopher Duggan, Daniel H. Teitelbaum, Paul W. Wales, Jane Balint, Robert Venick, Susan Rhee, Debra Sudan, David Mercer, J. Andres Martinez, Beth A. Carter, Jason Soden, Simon Horslen, Jeffrey A. Rudolph, Samuel Kocoshis, Riccardo Superina, Sharon Lawlor, Tamara Haller, Marcia Kurs-Lasky, Steven H. Belle, Pediatric Intestinal Failure Consortium ∗
- 50 Years Ago in The Journal of Pediatrics : The Surgical Management of Meningoceles and Meningomyeloceles
- Robert M. Lober, Paul Graham Fisher
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?