Single-nucleotide polymorphisms in genes involved in placental function and unexplained stillbirth - 27/09/12
, Fabio Facchinetti, MD a, Huaizhi Yin b, George R. Saade, MD b, Monica Longo, MD, PhD b
Reprints: Francesca Ferrari, MD, Obstetrics and Gynecology, Mother-Infant Department, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41100 Modena, ItalyRésumé |
Objective |
The purpose of this study was to evaluate the association between unexplained stillbirth (SB) and single-nucleotide polymorphisms (SNPs) in genes involved in placental function using a well-characterized cohort.
Study Design |
Placentas were obtained from 50 unexplained SB and 46 live birth controls. Classification of stillbirth was by Wigglesworth criteria. SBs were stratified by weight: appropriate (AGA-SB) and small for gestational age (SGA-SB, less than the 10th percentile) and gestational age: before 32 and after 32 weeks. Placental DNA was extracted and various SNPs in the endothelial nitric oxide synthase (eNOS), Klotho, hypoxic inducible factor-1⍺, and and tumor necrosis factor-⍺ genes were evaluated.
Results |
None of the SNPs were associated with SB overall. Significantly different genotype distribution emerged for eNOS-SNP rs1800783 when comparing AGA-SB with SGA-SB and control (P = .004). Its allele-A was more frequent in AGA-SB compared with both controls (P = .03) and SGA-SB (P = .001). No differences were seen accordingly to gestational age.
Conclusion |
Unexplained stillbirth in the setting of adequate growth is associated with carrier of allele A of rs1800783 eNOS gene in the placenta.
Le texte complet de cet article est disponible en PDF.Key words : endothelial nitric oxide synthase, placenta, polymorphism, stillbirth, unexplained
Plan
| The authors report no conflict of interest. |
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| Cite this article as: Ferrari F, Facchinetti F, Yin H, et al. Single-nucleotide polymorphisms in genes involved in placental function and unexplained stillbirth. Am J Obstet Gynecol 2012;207:316.e1-7. |
Vol 207 - N° 4
P. 316.e1-316.e7 - octobre 2012 Retour au numéro
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