Knowledge of regional and topographic anatomy is paramount for success when using minimally invasive plate osteosynthesis (MIPO) for fracture management. Preoperative planning is essential for an optimal outcome and reducing stress among the surgical team; factors to consider include biologic assessment, mechanical assessment, clinical assessment, portal placement, and implant selection. MIPO is a useful technique for the direct or indirect reduction of humeral diaphyseal fractures. Implants should span the length of the bone for ease of implant application and to optimize the mechanical advantage of the implant. After surgery, incision care and controlled activity are 2 primary considerations.