Mortality and Malignancy in Celiac Disease - 18/10/12
Department of Pediatrics, Örebro University Hospital, Örebro 701 85, Sweden.Résumé |
This article reviews the risk of mortality and malignancy in celiac disease (CD) and examines the evidence of the protective effect of a gluten-free diet (GFD) on mortality and malignancy. Population-based studies have confirmed that patients with diagnosed CD are at increased risk of mortality. However, patients with CD do not seem to be at an increased risk of malignancy, except for an increased risk of lymphoproliferative malignancy and gastrointestinal cancer. The evidence that a GFD reduces the risk of mortality is weak, but there is some evidence suggesting that a GFD may reduce the risk of lymphoproliferative malignancy.
Le texte complet de cet article est disponible en PDF.Keywords : Autoimmunity, Cancer, Celiac, Death, Epidemiology, Gluten, Lymphoma, Malignancy
Plan
| Disclosure/conflict of interest declaration: None. |
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| Grant support (funding): JFL was supported by grants from the Swedish Society of Medicine, the Swedish Research Council – Medicine (522-2A09-195), the Swedish Celiac Society, and the Fulbright commission. |
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| Independence (role of the sponsors): None of the funders had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the article. |
Vol 22 - N° 4
P. 705-722 - octobre 2012 Retour au numéro
Article précédent
- Management of Celiac Disease
- Ikram Nasr, Daniel A. Leffler, Paul J. Ciclitira
- Non-celiac Gluten Sensitivity
- Knut E.A. Lundin, Armin Alaedini
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