Soft-tissue infections encompass a wide spectrum of presentations ranging from superficial skin infection (cellulitis) to deep-seated infection (myositis and fasciitis), based on the depth and the area of involvement. Although less frequent, necrotizing soft-tissue infections (NSTIs) occur based on the interactions between the host factors and the causative pathogens. NSTIs are rapidly progressing and aggressive infections that can be lethal, with high morbidity and mortality. This article reviews some of the causative agents of NSTIs, clinical features, and the need for high index of suspicion for early recognition and prompt surgical and medical management.