Transabdominal amnioinfusion for preterm premature rupture of membranes: a systematic review and metaanalysis of randomized and observational studies - 30/10/12
Résumé |
Objective |
The purpose of this study was to review systematically the efficacy of transabdominal amnioinfusion (TA) in early preterm premature rupture of membranes (PPROM).
Study Design |
We conducted a literature search of EMBASE, MEDLINE, and www.clinicaltrials.gov databases and identified studies in which TA was used in cases of proven PPROM and oligohydramnios. Risk of bias was assessed for observational studies and randomized controlled trials. Primary outcomes were latency period and perinatal mortality rates.
Results |
Four observational studies (n = 147) and 3 randomized controlled trials (n = 165) were eligible. Pooled latency period was 14.4 (range, 8.2–20.6) and 11.41 (range −3.4 to 26.2) days longer in the TA group in the observational and the randomized controlled trials, respectively. Perinatal mortality rates were reduced among the treatment groups in both the observational studies (odds ratio, 0.12; 95% confidence interval, 0.02–0.61) and the randomized controlled trials (odds ratio, 0.33; 95% confidence interval, 0.10–1.12).
Conclusion |
Serial TA for early PPROM may improve early PPROM-associated morbidity and mortality rates. Additional adequately powered randomized control trials are needed.
Le texte complet de cet article est disponible en PDF.Key words : amnioinfusion, latency period, oligohydramnios, PPROM, pulmonary hypoplasia
Plan
| The authors report no conflict of interest. |
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| Reprints not available from the authors. |
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| Cite this article as: Porat S, Amsalem H, Shah PS, et al. Transabdominal amnioinfusion for premature preterm rupture of membranes: a systematic review and metaanalysis of randomized and observational studies. Am J Obstet Gynecol 2012;207:393.e1-11. |
Vol 207 - N° 5
P. 393.e1-393.e11 - novembre 2012 Retour au numéro
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