Filaggrin loss-of-function mutations do not predict food allergy over and above the risk of food sensitization among infants - 31/10/12

Doi : 10.1016/j.jaci.2012.07.022

Hern-Tze Tina Tan, BBiomedSc ^a,^b, Justine A. Ellis, PhD ^a,^c, Jennifer J. Koplin, PhD ^a, Melanie C. Matheson, PhD ^d, Lyle C. Gurrin, PhD ^a,^d, Adrian J. Lowe, PhD ^a,^d, Pamela E. Martin, BBiomedSc (Hons) ^a,^b, Thanh D. Dang, BBiomedSc (Hons) ^a,^b, Melissa Wake, MD, FRACP, MBBS ^a,^b,^e, Mimi L.K. Tang, MBBS, FRACP, FRCPA, FAAAAI, PhD ^a,^b,^f, Anne-Louise Ponsonby, BMedSci, MBBS, PhD, FAFPHM, FRACP ^a,^b, Shyamali C. Dharmage, MBBS, MSc, MD, PhD ^a,^d, Katrina J. Allen, MBBS, FRACP, PhD ^a,^b,^f
HealthNuts Study Investigators
The HealthNuts investigators include Nicholas Osborne, David Hill, Leone Thiele, Helen Czech, Deborah Anderson, Marnie Robinson, Dean Tey, Jeeva Sanjeevan, John Zurzolo, Lucy Miles, Kate Birch, Kelley Mancer, Marg Sutherland, and Marjolein Slaa. Ethics approval was obtained from the Office for Children HREC (reference no. CDF/07/492), the Department of Human Services HREC (reference no. 10/07), and the Royal Children’s Hospital HREC (reference no. 27047).
^a Murdoch Childrens Research Institute, Royal Children’s Hospital, Melbourne, Australia
^e Centre for Community Child Health, Royal Children’s Hospital, Melbourne, Australia
^f Department of Allergy and Immunology, Royal Children’s Hospital, Melbourne, Australia
^b Department of Paediatrics, University of Melbourne, Melbourne, Australia
^c Department of Physiology, University of Melbourne, Melbourne, Australia
^d Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia

Supported by the Australian National Health & Medical Research Council (NHMRC), the Ilhan Food Allergy Foundation, AnaphylaxiStop, and the Victorian Government’s Operational Infrastructure Support Program. K.J.A. is a Viertel Senior Medical Research Fellow, J.A.E. and J.J.K. are supported by an NHMRC Capacity Building Grant in Population Health, and M.C.M., L.C.G., A.J.L., M.W., A.-L.P., and S.C.D. hold NHMRC Awards. H.-T.T.T. is a recipient of a Malaysian Government ASTS Scholarship, and T.D.D. is an Australian Postgraduate Award scholar.

Disclosure of potential conflict of interest: A. J. Lowe, M. Wake, and A.-L. Ponsonby have been supported by one or more grants from the National Health & Medical Research Council of Australia. M. L. K. Tang receives research support from Phadia. K. J. Allen receives speaker’s fees from Nutricia/Danone, Pfizer, Wyeth, and Abbott. The rest of the authors declare that they have no relevant conflicts of interest.

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Vol 130 - N° 5

P. 1211 - novembre 2012 Retour au numéro

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Filaggrin loss-of-function mutations do not predict food allergy over and above the risk of food sensitization among infants - 31/10/12

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