Deep endoscopic access using double- and single-balloon enteroscopes and rotational endoscopy has vastly improved endoscopic therapeutic options in the small intestine. In this new era of interventional enteroscopy, significant advances have been made in the endoscopic treatment of small bowel polyps, angioectasias, and strictures. Although a decade ago small bowel polyps arising in the setting of a polyposis syndrome such as Peutz-Jeghers would have necessitated surgical resection, today endoscopic resection can typically be performed with positive clinical results. This article describes the current endoscopic management of small bowel polyps, arteriovenous malformations, strictures, and miscellaneous lesions identified within the small intestine.