Low Oxygen Saturation Target Range is Associated with Increased Incidence of Intermittent Hypoxemia - 20/11/12
, Michele Walsh, MD 1, Lisa Wrage, MPH 2, Wade Rich, RRT 3, Neil Finer, MD 3, Waldemar A. Carlo, MD 4, Richard J. Martin, MD 1SUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Reprint requests: Juliann M. Di Fiore, BSEE, Division of Neonatology, Room 3100, Rainbow Babies and Children’s Hospital, 11100 Euclid Ave, Cleveland, OH 44106.Abstract |
Objective |
To test the hypothesis that preterm infants randomized to a low vs high O2 saturation target range have a higher incidence of intermittent hypoxemia.
Study design |
A subcohort of 115 preterm infants with high resolution pulse oximetry enrolled in the Surfactant, Positive Pressure, and Oxygenation Randomized Trial were randomized to low (85%-89%) or high (91%-95%) O2 saturation target ranges. Oxygen saturation was monitored until 36 weeks postmenstrual age or until the infant was breathing room air without respiratory support for ≥72 hours.
Results |
The low target O2 saturation group had a higher rate of intermittent hypoxemia (≤80% for ≥10 seconds and ≤3 minutes) prior to 12 days and beyond 57 days of life (P < .05). The duration shortened (P < .0001) and the severity increased (P < .0001) with increasing postnatal age with no differences between target saturation groups. The higher rate of intermittent hypoxemia events in the low target group was associated with a time interval between events of <1 minute.
Conclusion |
A low O2 saturation target was associated with an increased rate of intermittent hypoxemia events that was dependent on postnatal age. The duration and severity of events was comparable between target groups. Further investigation is needed to assess the role of intermittent hypoxemia and their timing on neonatal morbidity.
Le texte complet de cet article est disponible en PDF.Keyword : GA, GEE, PMA, RR, ROP, ROS, SaO2, SUPPORT
Plan
| Supported by grants from the National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Heart, Lung, and Blood Institute (NHLBI), and the National Institute of Child Health and Human Development Cooperative Multicenter Neonatal Research Network (HD021364-23). Data collected at participating sites of the NICHD Neonatal Research Network were transmitted to RTI International, the data coordinating center for the network, which stored, managed, and analyzed the data for this study. The authors declare no conflicts of interest. |
Vol 161 - N° 6
P. 1047 - décembre 2012 Retour au numéro
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