The ischemic dermatopathies are a group of vasculopathic diseases that share clinical and histologic features but result from variable causes. Generalized ischemic dermatopathies are typically characterized by atrophic lesions with erythema, scale/crust, erosions/ulcerations, and pigmentary changes. Lesions may affect the toes, tail tip, pinnal margins, bony prominences, or any combination of these areas. Familial dermatomyositis (FDM) most commonly occurs in juvenile collies and Shetland sheepdogs. Ischemic reactions to rabies vaccines may mimic FDM and can occur in any breed. The most reliable symptomatic therapy for any form of ischemic dermatopathy is the combination of pentoxifylline and vitamin E.