Evaluation with a focus on both the antimicrobial efficacy and cumulative skin irritation potential of chlorhexidine gluconate alcohol–containing preoperative skin preparations - 29/11/12
, Takumi Kajiura, PhD a, Katsuhiro Yokota a, Hiroyoshi Kobayashi, MD, PhD b, Takashi Okubo, MD, PhD b
Address correspondence to Yutaka Nishihara, PhD, Yoshida Pharmaceutical Co, Ltd, 951 Minamiiriso, Sayama City, Saitama 350-1316, Japan.Abstract |
Background |
Important characteristics for ideal skin preparations include long-lasting antimicrobial efficacy and low potential for skin irritation.
Methods |
A total of 55 healthy adult subjects were enrolled to evaluate the antimicrobial effects of 3 test formulations applied to inguinal, abdominal, and antecubital sites at post-treatment time points of 30 seconds, 72 hours, and 7 days. To investigate skin irritation potential, the 3 formulations were tested in a 21-day repeat-insult patch test conducted on the skin of the backs of 23 healthy subjects.
Results |
The mean log10 reduction (MLR) at 7 days post-treatment produced by a 79% vol/vol ethanol containing 1% wt/vol chlorhexidine gluconate (1% CHG-EtOH) applied to abdominal sites was significantly superior to that produced by a 10% povidone-iodine solution (2.45 MLR vs 0.90 MLR; P < .05). The 1% CHG-EtOH and a 70% vol/vol isopropanol containing 2% wt/vol CHG (2% CHG-IPA) provided statistically equivalent persistence at 72 hours and 7 days post-treatment. The 1% CHG-EtOH had less skin irritation poetntial than the 2% CHG-IPA and the 10% povidone-iodine solution, although the differences were not statistically significant (P > .05).
Conclusion |
Considering its persistent effect and low skin irritation potential, the 1% CHG-EtOH preparation is expected to perform well in surgical site preparation to reduce the risk of surgery- and catheter-related bloodstream infection.
Le texte complet de cet article est disponible en PDF.Key Words : CHG, Catheter-related bloodstream infection, CRBSI, CDC guideline, RIPT, Repeat-insult patch test
Plan
| Conflict of interest: None to report. |
Vol 40 - N° 10
P. 973-978 - décembre 2012 Retour au numéro
Article précédent
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