Aberrant Paralimbic Gray Matter in Incarcerated Male Adolescents With Psychopathic Traits - 27/12/12
Correspondence to Elsa Ermer, Ph.D., Adelphi University, Psychology, 1 South Ave., Garden City, NY 11530.Abstract |
Objective |
To investigate the relationship between brain structure and psychopathic traits in maximum-security incarcerated male adolescents, and to examine whether the associations between brain volumes in paralimbic and limbic regions and psychopathic traits observed in incarcerated adult men extend to an independent sample of incarcerated male adolescents.
Method |
A structural magnetic resonance imaging (MRI) study of regional gray matter volumes by using voxel-based morphometry in maximum-security incarcerated male adolescents (N = 218) assessed for psychopathic traits using the Hare Psychopathy Checklist–Youth Version (PCL-YV). All analyses controlled for effects of age, substance use, and brain size.
Results |
Consistent with hypotheses and the adult literature, psychopathic traits were associated with decreased regional gray matter volumes in diffuse paralimbic regions, including orbitofrontal cortex, bilateral temporal poles, and posterior cingulate cortex.
Conclusions |
These results strengthen the interpretation that paralimbic regions are central for understanding neural dysfunction associated with psychopathic traits and that psychopathy is best conceptualized as a neurodevelopmental disorder.
Le texte complet de cet article est disponible en PDF.Key Words : paralimbic dysfunction, juvenile delinquency, voxel-based morphometry, psychopathy, antisocial
Plan
| This article is discussed in an editorial by Dr. Tonya J.H. White on page 9. |
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| This study was funded by the National Institute of Mental Health (NIMH) grant MH071896 (K.A.K., PI) and by NIMH National Research Service Award F32 MH086247 (E.E.). |
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| The authors are grateful to the staff, clients, and clients’ parents at the Youth Diagnostic and Detention Facility and the New Mexico Children, Youth and Families Department for their support and assistance in making this research possible. |
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| Disclosure: Dr. Calhoun has received research support from the National Institutes of Health (NIH), NIMH, the National Institute of Drug Abuse (NIDA), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Center for Research Resources, the National Science Foundation, the Defense Advanced Research Projects Agency, and the Department of Energy. He has served as a legal consultant, performed grant reviews for NIH, guest-edited journal sections, given academic lectures in various scientific venues, and generated books or book chapters for publishers of various texts. Dr. Kiehl has received grant support from NIH, NIMH, NIDA, NIBIB, NIAAA, and the John D. and Catherine T. MacArthur Foundation. He has performed grant reviews for NIH and other agencies, given academic lectures in various scientific venues and universities, and served as a consultant on judicial education for the states of Arizona, California, Illinois, Missouri, New Hampshire, and Nevada. Dr. Ermer, Ms. Cope, and Mr. Nyalakanti report no biomedical financial interests or potential conflicts of interest. |
Vol 52 - N° 1
P. 94 - janvier 2013 Retour au numéro
Article précédent
- Amygdala Habituation and Prefrontal Functional Connectivity in Youth With Autism Spectrum Disorders
- Johnna R. Swartz, Jillian Lee Wiggins, Melisa Carrasco, Catherine Lord, Christopher S. Monk
- Assistant Editor’s Note
- Schuyler Wheelock Henderson
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