Pulmonary circulatory changes after bilateral total knee arthroplasty during regional anesthesia - 07/02/13
: Clinical and Research Fellow, Stavros G. Memtsoudis, MD, PhD, FCCP a : Associate Professor and Associate Attending, George Go, BS a : Research Assistant, Yan Ma, PhD, FCCP c : Assistant Professor, Thomas Sculco, MD d : Professor and Chairman, Nigel Sharrock, BMedSci, MB, ChB a : Professor and AttendingAbstract |
Study Objective |
To monitor the pulmonary hemodynamics of patients undergoing bilateral total knee arthroplasty (BTKA) intraoperatively and up to 24 hours following surgery.
Design |
Prospective observational study.
Setting |
University-affiliated teaching hospital.
Patients |
30 ASA physical status 2 and 3 patients scheduled for single-stage, cemented BTKA during epidural anesthesia.
Interventions |
Pulmonary artery catheters were in all patients.
Measurements |
Systemic vascular resistance (SVR), pulmonary vascular resistance (PVR), the ratio of PVR to SVR at baseline, at the beginning of surgery, and after each knee implantation were recorded and compared with measurements taken one day postoperatively (POD 1).
Main Results |
On POD 1, PVR/SVR was increased by 30% compared with baseline (P < 0.0001) and by 20% versus the end of surgery (P < 0.0001). Systemic vascular resistance decreased during surgery and was significantly lower than baseline at 24 hours after surgery (P < 0.0001). No significant change in PVR was noted during surgery.
Conclusion |
The PVR/SVR ratio on the day following BTKA was increased. This change may represent the different effects of inflammatory perioperative stresses on the pulmonary and systemic vasculature.
Le texte complet de cet article est disponible en PDF.Keywords : Bilateral knee arthroplasty, Epidural anesthesia, Pulmonary hemodynamics
Plan
| ☆ | Supported by an Anesthesiology Young Investigator Award from the Department of Anesthesiology, Hospital for Special Surgery (Stavros G. Memtsoudis), and grants from the Center for Education and Research in Therapeutics (AHRQ RFAHS-05-14) and Clinical Translational Science Center (NIH UL1-RR024996) (Yan Ma). |
| ☆☆ | The authors have no conflicts of interest to report. |
Vol 25 - N° 1
P. 4-8 - février 2013 Retour au numéro
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