Hyperglycemia after solid organ transplantation increases the risk for wound infection, poor healing time, graft rejection, and graft loss. In patients without a history of diabetes, uncontrolled hyperglycemia increases the risk for advancement to diabetes mellitus. Controlling hyperglycemia can reduce the prevalence of new-onset diabetes after transplantation. This article discusses the current literature concerning blood glucose management after solid organ transplantation, the issues surrounding hyperglycemia in the patient with a solid organ transplant, and how to manage hyperglycemia after solid organ transplant.