A Review of Contemporary Data on Surgically Resected Renal Masses—Benign or Malignant? - 27/03/13
Abstract |
Objective |
To clearly define the proportions of benign vs malignant histologic findings in resected renal masses through an in-depth review of the contemporary medical data to assist in preoperative risk assessment.
Materials and Methods |
PubMed and select oncology congresses were searched for publications that identify the histologic classification of resected renal masses in a representative sample from the contemporary data: [search] incidence AND (renal cell carcinoma AND benign); incidence AND (renal tumor AND benign); percentage AND (renal cell carcinoma AND benign); limit 2003-2011.
Results |
We identified 26 representative studies meeting the inclusion criteria and incorporating 27,272 patients. The frequency of benign tumors ranged from 7% to 33%, with most studies within a few percentage points of the mean (14.5% ± 5.2%, median 13.9%). Clear cell renal cell carcinoma occurred in 46% to 83% of patients, with a mean of 68.3% (median 61.3; SD = 11.9%). An inverse relationship between tumor size and benign pathologic features was identified in 14 of 19 (74%) studies that examined an association between tumor size and pathologic characteristics. A statistically significant correlation between clear cell renal cell carcinoma and tumor size was identified in 13 of 19 studies (63%). The accuracy of preoperative cross-sectional imaging was low in the 2 studies examining computed tomography (17%).
Conclusion |
Benign renal tumors represent 15% of detected surgically resected renal masses and are more prevalent among small clinical T1a lesions. Noninvasive preoperative differentiation between more and less aggressive renal masses would be an important clinical advance that could allow clinicians greater diagnostic confidence and guide patient management through improved risk stratification.
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Financial Disclosure: The authors declare that they have no relevant financial interests. |
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Funding Support: IBA Molecular (Dulles, VA) funded editorial support (literature search, document retrieval, and medical writing) for manuscript development, which was provided by Jeffrey Coleman, MA, Michael Theisen, PhD, and Kris Schuler, MS, of Complete Healthcare Communications, Inc. (Chadds Ford, PA). |
Vol 81 - N° 4
P. 707-713 - avril 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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