PET Parametric Response Mapping for Clinical Monitoring and Treatment Response Evaluation in Brain Tumors - 30/03/13

Doi : 10.1016/j.cpet.2012.09.002

Benjamin M. Ellingson, PhD ^a,^b,^c,^⁎ , Wei Chen, MD ^d, Robert J. Harris, BS ^a,^b, Whitney B. Pope, MD, PhD ^a, Albert Lai, MD, PhD ^e, Phioanh L. Nghiemphu, MD ^e, Johannes Czernin, MD ^d, Michael E. Phelps, PhD ^d, Timothy F. Cloughesy, MD ^e
^a Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
^b Department of Biomedical Physics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
^c Department of Biomedical Engineering, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
^d Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
^e Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA

Corresponding author. Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Boulevard, Suite 615, Los Angeles, CA 90024.

Résumé

PET parametric response maps (PRMs) are a provocative new molecular imaging technique for quantifying brain tumor response to therapy in individual patients. By aligning sequential PET scans over time using anatomic MR imaging information, the voxel-wise change in radiotracer uptake can be quantified and visualized. PET PRMs can be performed before and after a particular therapy to test whether the tumor is responding favorably, or performed relative to a distant time point to monitor changes through the course of a treatment. This article focuses on many of the technical details involved in generating, visualizing, and quantifying PET PRMs, and practical applications and example case studies.

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Keywords : PET, PET parametric response maps, Glioblastoma, GBM, Brain tumors, Imaging, Response, Biomarker

Plan

Key points

Introduction

Common PET tracers in brain tumors

Amino Acid Tracers

Proliferation Tracers

Hypoxia Tracers

The PET parametric response map

PET PRM Methodology

Threshold for PET PRM Classification Using Voxel-Wise Variation in PET Uptake

Quantification of PET PRMs

PET PRMs as a biomarker for early treatment response

PET PRMs for serial clinical monitoring

Technical limitations of PET PRMs

Future directions

Summary

Funding: UCLA Institute for Molecular Medicine Seed Grant (BME); UCLA Radiology Exploratory Research Grant (BME); University of California Cancer Research Coordinating Committee Grant (BME); ACRIN Young Investigator Initiative Grant (BME); Art of the Brain (TFC); Ziering Family Foundation in memory of Sigi Ziering (TFC); Singleton Family Foundation (TFC); Clarence Klein Fund for Neuro-Oncology (TFC).

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Vol 8 - N° 2

P. 201-217 - avril 2013 Retour au numéro

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PET Parametric Response Mapping for Clinical Monitoring and Treatment Response Evaluation in Brain Tumors - 30/03/13

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