B-lymphocyte lineage cells and the respiratory system - 30/03/13
Abstract |
Adaptive humoral immune responses in the airways are mediated by B cells and plasma cells that express highly evolved and specific receptors and produce immunoglobulins of most isotypes. In some cases, such as autoimmune diseases or inflammatory diseases caused by excessive exposure to foreign antigens, these same immune cells can cause disease by virtue of overly vigorous responses. This review discusses the generation, differentiation, signaling, activation, and recruitment pathways of B cells and plasma cells, with special emphasis on unique characteristics of subsets of these cells functioning within the respiratory system. The primary sensitization events that generate B cells responsible for effector responses throughout the airways usually occur in the upper airways, tonsils, and adenoid structures that make up the Waldeyer ring. On secondary exposure to antigen in the airways, antigen-processing dendritic cells migrate into secondary lymphoid organs, such as lymph nodes, that drain the upper and lower airways, and further B-cell expansion takes place at those sites. Antigen exposure in the upper or lower airways can also drive expansion of B-lineage cells in the airway mucosal tissue and lead to the formation of inducible lymphoid follicles or aggregates that can mediate local immunity or disease.
Le texte complet de cet article est disponible en PDF.Key words : B cells, plasma cells, plasmablasts, respiratory diseases
Abbreviations used : AID, APRIL, BAFF, BAL, BCMA, BCR, BLNK, BTK, CD40L, COPD, CRS, CRSwNP, CSR, CTD, CVID, DC, EBI2, ERK, GC, GOLD, HEV, HP, iBALT, IC, ILF, iNOS, IPF, IRF, LN, MAPK, MyD88, MZ, NALT, NF-κB, NIK, OB, OVA, PI3K, pIgR, PIP3, PKC, PLCγ2, PP, RA, SHM, sIgA, SLE, SLO, STAT, SYK, TACI, TFH, TLR
Plan
Series editors: Donald Y. M. Leung, MD, PhD, and Dennis K. Ledford, MD |
|
Supported in part by National Institutes of Health grants K23DC012067, R01 HL078860, R01 AI072570, and R37 HL068546 and by a grant from the Ernest S. Bazley Trust. |
Vol 131 - N° 4
P. 933-957 - avril 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?