Takotsubo Cardiomyopathy : Overview - 03/04/13

Doi : 10.1016/j.hfc.2012.12.015

Eduardo Bossone, MD, PhD, FESC ^a,^b, Gianluigi Savarese, MD ^c, Francesco Ferrara, MD ^b,^d, Rodolfo Citro, MD, FESC ^b, Susanna Mosca, MD ^c, Francesca Musella, MD ^c, Giuseppe Limongelli, MD, PhD, FESC ^e, Roberto Manfredini, MD ^f, Antonio Cittadini, MD, PhD ^d, Pasquale Perrone Filardi, MD, PhD ^c,^⁎
^a Department of Cardiac Surgery, IRCCS Policlinico San Donato, Piazza Edmondo Malan 1, 20097 San Donato Milanese, Italy
^b Department of Cardiology and Cardiac Surgery, University Hospital “Scuola Medica Salernitana”, Via De Marinis - 84013 Cava de’ Tirreni, Salerno, Italy
^c Department of Advanced Biomedical Sciences, Federico II University, Via Pansini, 5 - 80131 Naples, Italy
^d Department of Medical Translational Sciences, Federico II University, Via Pansini, 5 - 80131 Naples, Italy
^e Department of Cardiology, Monaldi Hospital, Second University of Naples, Via L. Bianchi - 80100 Naples, Italy
^f Section of Clinica Medica, Department of Clinical and Experimental Medicine, University of Ferrara, Via Aldo Moro - 44020 Ferrara, Italy

Corresponding author. Department of Advanced Biomedical Sciences, Federico II University; Via Pansini, 5 - 80131 Naples, Italy.

Résumé

Takotsubo cardiomyopathy (TTC) is a unique acute syndrome characterized by transient left ventricular systolic dysfunction in the absence of significant coronary artery disease, occurring mostly in postmenopausal women after emotional and/or physical stress. Given the nonspecific symptoms and signs, a high clinical index of suspicion is necessary to detect the disease in different clinical settings and scenarios. Noninvasive multimodality imaging may be useful to distinguish this cardiomyopathy from other acute cardiac and thoracic diseases. Coronary angiography remains, however, mandatory to differentiate TTC from acute coronary syndromes. This article reviews the clinical features and management of TTC and some new insights.

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Keywords : Takotsubo cardiomyopathy, Apical ballooning, Stress cardiomyopathy