MBL Versus CLL : How Important Is the Distinction? - 04/04/13
Corresponding author.Résumé |
Monoclonal B-cell lymphocytosis (MBL) is defined as a clonal B-cell expansion whereby the B-cell count is less than 5 × 109/L and no symptoms or signs of lymphoproliferative disorders are detected. Based on B-cell count, MBL is further divided into low-count and clinical MBL. While low-count MBL seems to carry relevance mostly from an immunological perspective, clinical MBL and chronic lymphocytic leukemia appear to be overlapping entities. Only a deeper knowledge of molecular pathways and microenvironmental influences involved in disease evolution will help to solve the main clinical issue, i.e. how to differentiate nonprogressive and progressive cases requiring intensive follow-up.
Le texte complet de cet article est disponible en PDF.Keywords : Monoclonal B-cell lymphocytosis, Chronic lymphocytic leukemia, Immunoglobulin genes, Chromosomal aberrations, Progression, Prognosis, Immunophenotype, Immune system
Plan
Vol 27 - N° 2
P. 251-265 - avril 2013 Retour au numéro
Article précédent
- The Significance of Stereotyped B-Cell Receptors in Chronic Lymphocytic Leukemia
- Nikos Darzentas, Kostas Stamatopoulos
- The Role of Minimal Residual Disease Measurements in the Therapy for CLL : Is It Ready for Prime Time?
- Sebastian Böttcher, Michael Hallek, Matthias Ritgen, Michael Kneba
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