Does Overall Diet in Midlife Predict Future Aging Phenotypes? A Cohort Study - 12/04/13
, Séverine Sabia, PhD a, d, Gareth Hagger-Johnson, PhD a, Adam G. Tabak, MD a, e, Martin J. Shipley, MSc a, Markus Jokela, PhD a, f, g, Eric J. Brunner, PhD a, Mark Hamer, PhD a, G. David Batty, PhD a, h, Archana Singh-Manoux, PhD a, d, Mika Kivimaki, PhD a
Requests for reprints should be addressed to Tasnime Akbaraly, PhD, Inserm U 1061, Hôpital La Colombière, 39 avenue Charles Flahault, BP 34493, 34093 Montpellier cedex 05, FranceAbstract |
Background |
The impact of diet on specific age-related diseases has been studied extensively, but few investigations have adopted a more holistic approach to determine the association of diet with overall health at older ages. We examined whether diet, assessed in midlife, using dietary patterns and adherence to the Alternative Healthy Eating Index (AHEI), is associated with aging phenotypes, identified after a mean 16-year follow-up.
Methods |
Data were drawn from the Whitehall II cohort study of 5350 adults (age 51.3±5.3 years, 29.4% women). Diet was assessed at baseline (1991-1993). Mortality, chronic diseases, and functioning were ascertained from hospital data, register linkage, and screenings every 5 years and were used to create 5 outcomes at follow-up: ideal aging (free of chronic conditions and high performance in physical, mental, and cognitive functioning tests; 4%), nonfatal cardiovascular event (7.3%), cardiovascular death (2.8%), noncardiovascular death (12.7%), and normal aging (73.2%).
Results |
Low adherence to the AHEI was associated with an increased risk of cardiovascular and noncardiovascular death. In addition, participants with a “Western-type” diet (characterized by high intakes of fried and sweet food, processed food and red meat, refined grains, and high-fat dairy products) had lower odds of ideal aging (odds ratio for top vs bottom tertile: 0.58; 95% confidence interval, 0.36-0.94; P=.02), independently of other health behaviors.
Conclusions |
By considering healthy aging as a composite of cardiovascular, metabolic, musculoskeletal, respiratory, mental, and cognitive function, the present study offers a new perspective on the impact of diet on aging phenotypes.
Le texte complet de cet article est disponible en PDF.Keywords : Aging, Cognitive functioning, Dietary patterns, Diet quality indices, Mortality, Nutritional epidemiology, Overall diet, Physical functioning
Plan
| Funding: The Whitehall II study is supported by grants from the British Medical Research Council (MRC) G8802774; the British Heart Foundation; the British Health and Safety Executive; the British Department of Health; the National Heart, Lung, and Blood Institute (R01HL036310); the National Institute on Aging, National Institutes of Health (R01AG013196 and R01AG034454); and the Agency for Health Care Policy and Research (grant HS06516). MK is supported by an ESRC professorship; TNA was supported by the Languedoc-Roussillon Region (Chercheur d’avenir Grant 2011). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
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| Conflict of Interest: None. |
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| Authorship: TNA, SS, GHJ, AGT, MJS, MJ, EJB, MH, GDB, ASM, MK designed research, TNA and MK conducted research. TNA analyzed data or performed statistical analysis; TNA and MK drafted the manuscript; TNA had primary responsibility for final content and SS, GHJ, AGT, MJS, MJ, EJB, MH, DB, ASM, MK made a critical revision of the manuscript for important intellectual content. |
Vol 126 - N° 5
P. 411 - mai 2013 Retour au numéro
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