Erythema multiforme during anti–tumor necrosis factor treatment for plaque psoriasis - 24/04/13
Abstract |
Tumor necrosis factor alpha (TNF-⍺) inhibitors constitute a class of biologic treatments utilized in the management of psoriasis. We report a case of a patient treated for chronic plaque psoriasis with the anti-TNF-⍺ monoclonal antibody adalimumab, who developed erythema multiforme (EM). The patient had previously developed EM on two occasions while taking the TNF-⍺ inhibitor etanercept. EM has previously been reported in connection with other TNF-⍺ inhibitors, including etanercept and infliximab. To our knowledge, this is the first case reported in the literature documenting EM occurring subsequent to adalimumab treatment for psoriasis. The recurrent development of EM in our patient while being treated with distinct TNF-⍺ inhibitors may suggest that EM is the consequence of a class effect with TNF-⍺ inhibitors.
Le texte complet de cet article est disponible en PDF.Key words : adalimumab, erythema multiforme, psoriasis, TNF-⍺, inhibitor
Abbreviations used : DIEM, EM, FDA, HAEM, HSV, IL, TNF, VZV
Plan
Funding sources: None. |
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Disclosure: Dr Chiu has been a paid consultant for Abbott, Amgen, Connetics, Galderma, and Warner-Chilcott; he has also been an investigator for Amgen. Ms Ahdout and Dr Haley have no relevant conflicts of interest. |
Vol 62 - N° 5
P. 874-879 - mai 2010 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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