Clinicopathologic study of node-negative advanced gastric cancer and analysis of factors predicting its recurrence and prognosis - 16/05/13
, Tsung-Hsing Chen, M.D. b, Chun-Jun Lin, M.D. b, Jeng-Hwei Tseng, M.D. c, Ta-Sen Yeh, M.D., Ph.D. a, Tsann-Long Hwang, M.D. a, Yi-Yin Jan, M.D. aAbstract |
Background |
This study aimed to reveal the predictors for the recurrence pattern of gastric cancer (GC) and analyze the prognostic factors in node-negative advanced (T2 to T4) GC after curative resection.
Methods |
Between 1994 and 2006, 448 patients with node-negative advanced GC undergoing radical resection were enrolled in this study. Clinicopathologic factors affecting the recurrence pattern and prognosis for GC were analyzed.
Results |
Location, size, tumor invasion depth, and perineural invasion were associated with tumor recurrence and outcome. T4 status was a predictor for locoregional recurrence and peritoneal seeding, and a large tumor size and the presence of perineural invasion predicted hematogenous spread. Patients with only locoregional recurrence had better survival than those with peritoneal seeding or hematogenous spread.
Conclusions |
In node-negative advanced GC, the prognostic factor differed significantly between locoregional recurrence/peritoneal seeding and hematogenous metastasis. Survival rates were higher in patients with locoregional recurrence alone than in patients with other recurrence patterns.
Le texte complet de cet article est disponible en PDF.Keywords : Advanced gastric adenocarcinoma, Node negative, Recurrence pattern, Prognostic factor
Plan
| Supported in part by the Chang Gung Medical Research Program, Taiwan (CMRPG 380161), and the grants of Department of Health, Taiwan (DOH99-TD-C-111-006; PMRPG390071). |
Vol 205 - N° 6
P. 623-630 - juin 2013 Retour au numéro
Article précédent
- Table of Contents
- Association study of integrins beta 1 and beta 2 gene polymorphism and papillary thyroid cancer
- Young Gyu Eun, Su Kang Kim, Joo-Ho Chung, Kee Hwan Kwon
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?