Ceric ammonium nitrate (CAN) catalysed expeditious one-pot synthesis of 1,3-thiazine as IspE kinase inhibitor of Gram-negative bacteria using polyethylene glycol (PEG-400) as an efficient recyclable reaction medium - 31/05/13

Doi : 10.1016/j.crci.2012.11.019

Udaya Pratap Singh ^a,^b,^⁎,^{^{1
Present address: Archimedes DoRa5 Visiting Fellow, Division of Bio-organic Chemistry, Institute of Chemistry, University of Tartu, Estonia.}} , Hans Raj Bhat ^a, Ramendra Kumar Singh ^b,^⁎
^a Department of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Formerly Allahabad Agricultural Institute, Deemed University, 211007 Allahabad, India
^b Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, 211002 Allahabad, India

Corresponding author. Department of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Formerly Allahabad Agricultural Institute, Deemed University, 211007 Allahabad, India.Corresponding author. Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, 211002 Allahabad, India.

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Abstract

A novel, simple, inexpensive and efficient ceric ammonium nitrate (CAN) catalysed one-pot, multi-component synthesis of 1,3-thiazine in PEG-400 has been developed. These derivatives were identified as potent inhibitor of Gram-negative bacteria and acted via inhibition of 4-diphosphocytidyl-2-Cmethyl-D-erythritol (IspE) kinase, a novel target.

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Keywords : CAN, PEG-400, 1,3-thiazine, Antibacterial

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Vol 16 - N° 5

P. 462-468 - mai 2013 Retour au numéro

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Ceric ammonium nitrate (CAN) catalysed expeditious one-pot synthesis of 1,3-thiazine as IspE kinase inhibitor of Gram-negative bacteria using polyethylene glycol (PEG-400) as an efficient recyclable reaction medium - 31/05/13

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