Impact of Haemophilus influenzae Type b Conjugate Vaccine in Mongolia: Prospective Population-Based Surveillance, 2002-2010 - 16/06/13
, Dorjpurev Altanseseg, MD, PhD 2, Demberelsuren Sodbayer, MD, MPH 3, Pagvajav Nymadawa, MD, PhD, DSc 2, Davaadash Bulgan, MD, PhD 2, Jamsran Mendsaikhan, MD, PhD 3, James P. Watt, MD, MPH 4, Mary P.E. Slack, MA, MBBChir, FRCPath 5, Maria G. Carvalho, PhD 6, Rana Hajjeh, MD 6, Karen M. Edmond, MBBS, MSc, MTPH, FRACP 1, 7Abstract |
Objectives |
Bacterial meningitis is associated with high mortality and long-term complications. This study assessed the impact of Haemophilus influenzae type b (Hib) conjugate vaccine on childhood bacterial meningitis in Ulaanbaatar, Mongolia.
Study design |
Prospective, active, population-based surveillance for suspected meningitis in children aged 2-59 months was conducted (February 2002-January 2011) in 6 hospitals. Clinical data, blood, and cerebrospinal fluid were collected. The impact of Hib conjugate vaccine was assessed by comparing Hib and all cause meningitis data in the 3 years preceding pentavalent conjugate vaccine implementation (2002-2004) with 3 years postimplementation (2008-2010).
Results |
Five hundred eleven cases of suspected meningitis were identified from 2002-2011. Pentavalent conjugate vaccine coverage in December 2005 in Ulaanbaatar city was 97%. The proportion of suspected cases confirmed as Hib meningitis decreased from 25% (50/201) in the prevaccination era to 2% (4/193) in the postvaccination era (P < .0001). The annual incidence of Hib decreased from 28 cases per 100 000 children in 2002-2005 to 2 per 100 000 in 2008-2010 (P < .0001).
Conclusions |
This article demonstrates the marked impact of Hib conjugate vaccine introduction on meningitis in Mongolia. It is important to sustain this surveillance system to monitor the long-term impact of Hib conjugate vaccine, as well as other interventions such as pneumococcal and meningococcal vaccines.
Le texte complet de cet article est disponible en PDF.Keyword : CSF, Hib, NCCD, PCR
Plan
| Please see the Author Disclosures at the end of this article. |
Vol 163 - N° 1S
P. S8-S11 - juillet 2013 Retour au numéro
Article précédent
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