Psoriasis as Autoinflammatory Disease - 03/07/13
, Wendell C. Valdecantos, MD aRésumé |
This article presents a summary of the evidence for a link between autoinflammatory diseases and psoriasis. The main concepts regarding the disease state of psoriasis are discussed and these lead to a change in the perspective on the clinical and pathophysiologic nature of psoriasis as a chronic, recurrent disease with important genetically defined features, and an associated or concomitant systemic inflammatory state that involves a multifactorial cellular and molecular network, transforming the old perception of psoriasis as a localized autoimmune skin disease, to one of psoriasis as a systemic inflammatory disease with autoinflammatory features and severe associated comorbid conditions.
Le texte complet de cet article est disponible en PDF.Keywords : Psoriasis, Autoinflammatory disease, Genetics, Immunopathogenesis, TH cells, TNF-α, Cytokines, Inflammasome
Plan
| Disclosures: Drs Joaquin Rivas and Wendell Valdecantos are employees of AbbVie. |
Vol 31 - N° 3
P. 445-460 - juillet 2013 Retour au numéro
Article précédent
- Role of Interleukin 1 in Atopic Dermatitis
- William Abramovits, Joaquin J. Rivas Bejarano, Wendell C. Valdecantos
- Autoinflammatory Disorders, Pain, and Neural Regulation of Inflammation
- Michael C. Chen, Matthew H. Meckfessel
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