Autoinflammatory Syndromes - 03/07/13
Résumé |
Autoinflammatory syndromes comprise a diagnostically challenging group of systemic inflammatory disorders uniquely related by (1) dysregulation of innate immunity, (2) inflammasome activation, (3) dramatic clinical features (high fevers, neutrophilic rashes, and bone or synovial involvement), (4) impressive acute phase responses, and (5) effective treatment with cytokine inhibitors. This review details some of the more common autoinflammatory disorders, their distinguishing features and dermatologic manifestations, and how an accurate diagnosis can be established in patients presenting with periodic or intermittent febrile disorders.
Le texte complet de cet article est disponible en PDF.Keywords : Autoinflammatory, CAPS, Periodic fever, Still disease
Plan
| Disclosures: Clinical investigator for Genentech, Pfizer, UCB, Celgene, Novartis, Amgen, NIH, and CORRONA; advisor and consultant to Janssen, Abbott, UCB, Pfizer, BMS, Amgen, Genentech, Savient, and Celgene. Dr Cush holds no stock or investments in these companies and does not partake in industry “speaker’s bureaus” or give industry-guided “promotional lectures.” |
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| Funded by: NIHU19 082715. |
Vol 31 - N° 3
P. 471-480 - juillet 2013 Retour au numéro
Article précédent
- Autoinflammatory Disorders, Pain, and Neural Regulation of Inflammation
- Michael C. Chen, Matthew H. Meckfessel
- Autoinflammatory Diseases in Pediatrics
- Jonathan S. Hausmann, Fatma Dedeoglu
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