Differences in cortical development assessed by fetal MRI in late-onset intrauterine growth restriction - 25/07/13
Abstract |
Objective |
The objective of the study was to evaluate cortical development parameters by magnetic resonance imaging (MRI) in late-onset intrauterine growth–restricted (IUGR) fetuses and normally grown fetuses.
Study Design |
A total of 52 IUGR and 50 control fetuses were imaged using a 3T MRI scanner at 37 weeks of gestational age. T2 half-Fourier acquisition single-shot turbo spin-echo anatomical acquisitions were obtained in 3 planes. Cortical sulcation (fissures depth corrected by biparietal diameter), brain volumetry, and asymmetry indices were assessed by means of manual delineation and compared between cases and controls.
Results |
Late-onset IUGR fetuses had significantly deeper measurements in the left insula (late-onset IUGR: 0.293 vs control: 0.267; P = .02) and right insula (0.379 vs 0.318; P < .01) and the left cingulate fissure (0.096 vs 0.087; P = .03) and significantly lower intracranial (441.25 cm3 vs 515.82 cm3; P < .01), brain (276.47 cm3 vs 312.07 cm3; P < .01), and left opercular volumes (2.52 cm3 vs 3.02 cm3; P < .01). IUGR fetuses showed significantly higher right insular asymmetry indices.
Conclusion |
Late-onset IUGR fetuses had a different pattern of cortical development assessed by MRI, supporting the existence of in utero brain reorganization. Cortical development could be useful to define fetal brain imaging-phenotypes characteristic of IUGR.
Le texte complet de cet article est disponible en PDF.Key words : brain volumetry, cortical sulcation, fetal brain imaging
Plan
| This work was supported by grants from the Cerebra Foundation for the Brain-Injured Child, Carmarthen, Wales, UK; the Thrasher Research Fund, Salt Lake City, UT; Obra Social “la Caixa,” Barcelona, Spain; and Banca Cívica de Caja Navarra (Proyecto TETD). G.E.-U. was supported by CONICYT (PFCHA/Doctorado al Extranjero 4a Convocatoria, grant 72120071), Chile. M.S.-C. was supported by the Instituto de Salud Carlos III Rio Hortega (grant CM10/00222), Spain. |
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| The authors report no conflict of interest. |
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| Reprints not available from the authors. |
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| Cite this article as: Egaña-Ugrinovic G, Sanz-Cortes M, Figueras F, et al. Differences in cortical development assessed by fetal MRI in late-onset intrauterine growth restriction. Am J Obstet Gynecol 2013;209:126.e1-8. |
Vol 209 - N° 2
P. 126.e1-126.e8 - août 2013 Retour au numéro
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