Amyloid PET Imaging : MCI and AD - 02/10/13
Résumé |
PET with “β-amyloid–specific” molecular imaging probes is proposed for the measurement of brain β-amyloid protein amyloidosis in the new guidelines for diagnosis of Alzheimer disease (AD) at different levels of disease progression. This article discusses limitations of this proposed use pointing to unresolved issues and inconsistencies between PET scan results and correlation with other biomarkers, and with postmortem histopathological studies. These unresolved issues do not warrant the conclusion that PET imaging with “β-amyloid–specific” molecular imaging probes can be used as a biomarker in AD or in the various stages of disease progression.
Le texte complet de cet article est disponible en PDF.Keywords : Alzheimer disease, Mild cognitive impairment, Positron emission tomography, “β-amyloid–specific” probes, Imaging biomarkers
Plan
| Funding Sources: National Institutes of Health (P50 AG16570). |
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| Conflict of Interest: None. |
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| The author received support from the Mary S. Easton Center of Alzheimer's Disease Research at UCLA (NIH P50 AG16570). |
Vol 8 - N° 4
P. 431-445 - octobre 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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