Cortical Folding Is Altered before Surgery in Infants with Congenital Heart Disease - 24/10/13
Doi : 10.1016/j.jpeds.2013.06.045
Cynthia Ortinau, MD 1, ⁎ 
, Dimitrios Alexopoulos, MS 1, Donna Dierker, MS 2, David Van Essen, PhD 2, John Beca, MBChB 3, Terrie Inder, MBChB, MD 1, 4, 5
, Dimitrios Alexopoulos, MS 1, Donna Dierker, MS 2, David Van Essen, PhD 2, John Beca, MBChB 3, Terrie Inder, MBChB, MD 1, 4, 5 1 Department of Pediatrics, St. Louis Children's Hospital, Washington University in St. Louis, St. Louis, MO
2 Departments of Anatomy and Neurobiology, Washington University in St. Louis, St. Louis, MO
3 Pediatric Intensive Care Unit, Starship Children's Hospital, Auckland, New Zealand
4 Department of Neurology, Washington University in St. Louis, St. Louis, MO
5 Mallinkrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO
∗Reprint requests: Cynthia Ortinau, MD, Department of Pediatrics, St. Louis Children's Hospital, Washington University in St. Louis, Campus Box 8116, 660 South Euclid Ave, St. Louis, MO 63110.
Abstract |
Infants with congenital heart disease have altered brain development. We characterized cortical folding, a critical part of brain development, in congenital heart disease infants and demonstrated an overall decrease in cortical surface area and cortical folding with regional alterations in the right lateral sulcus and left orbitofrontal region, cingulate region, and central sulcus. These abnormalities were present prior to surgery.
Le texte complet de cet article est disponible en PDF.Keyword : CHD, CSA, GI, MRI
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| Supported by the National Heart Foundation of New Zealand, the Green Lane Research and Education Fund, the Auckland Medical Research Fund, the Doris Duke Distinguished Clinical Scientist Award, the National Institutes of Health under Ruth L. Kirschstein National Research Service Award (T32 HD043010), Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD062171 and ), and the Washington University Institute of Clinical and Translational Sciences (UL1 TR000448 and KL2 TR000450) from the National Center for Advancing Translational Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The authors declare no conflicts of interest. |
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Vol 163 - N° 5
P. 1507-1510 - novembre 2013 Retour au numéro
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