Management of hereditary angioedema (HAE) has changed dramatically in recent years because of the availability of several HAE-specific medications. This paradigm shift in therapy provides the opportunity to dramatically improve the care of HAE patients, but has increased the complexity of treatment. Patient education and communication with health care providers is crucial. Early treatment of HAE attacks has been shown to improve clinical outcomes, highlighting the importance of rapid and reliable treatment. This review summarizes the current evidence for best practices in HAE management, and suggests practical steps toward developing a comprehensive treatment plan.