It is often necessary to restore bone structure following the loss of osseous substance. Therefore, the use of bone substitutes made of synthetic calcium phosphate (CaP) ceramics has become more widespread. Granular forms of these biomaterials have demonstrated osteogenic capacities within various sites. Recently, a combination of CaP microporous granules and hydrosoluble polymers was developed (In’Oss™). This composite material is non-self-hardening, injectable, and moldable. The purpose of this non-interventional clinical study was to demonstrate the safety and efficacy of these bioceramic/hydrogel bone substitutes in bone regeneration following maxillofacial surgery. In’Oss™ biomaterial was injected into bone defects created by tooth removal in 78 patients. Notably, no infectious or foreign body reactions were reported during at least 17months of follow up for the study. Regeneration of bone architecture was observed by histomorphometry.