Precursor B- or T-lymphoblastic lymphoma presenting with cutaneous involvement: A series of 13 cases including 7 cases of cutaneous T-lymphoblastic lymphoma - 16/01/14
Abstract |
Background |
Lymphoblastic lymphoma (LBL) is a rare neoplasm of precursor lymphocytes, and cutaneous involvement is present in less than 20% of cases.
Objective |
We sought to describe the clinical and histopathological features of cutaneous LBL.
Methods |
We retrospectively examined the clinical and histologic features of 13 patients with cutaneous LBL, 6 with B-LBL and 7 with T-LBL.
Results |
Five of 6 patients with B-LBL had lesions in the head and neck area, whereas 4 of 7 patients with T-LBL developed skin lesions on sites other than the head and neck. Seven patients (1 case of B-LBL, and 6 of 7 cases of T-LBL) developed multiple skin lesions, and the T-LBL cases frequently developed multiple skin lesions in the head, neck, and throughout the torso. Complete remission was achieved in 9 patients (3 patients with T-LBL and all patients with B-LBL).
Limitations |
This study used a retrospective design and included a small sample size.
Conclusion |
This study compared the clinical features of T-LBL and B-LBL, in particular the affected sites and number of skin lesions. Cutaneous T-LBL is likely to be accompanied by disseminated disease and has a relatively poor prognosis compared with B-LBL.
Le texte complet de cet article est disponible en PDF.Key words : lymphoblast, lymphoblastic lymphoma, lymphoma, precursor B lymphocytes, precursor T lymphocytes, skin
Abbreviations used : ALL, LBL, TdT
Plan
| Supported by the Asan Institute of Life Science. |
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| Conflicts of interest: None declared. |
Vol 70 - N° 2
P. 318-325 - février 2014 Retour au numéro
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