Genetic Susceptibility - 06/02/14
Doi : 10.1016/j.ccm.2013.10.008
Stefan J. Marciniak, PhD, FRCP a, b, ⁎ 
, David A. Lomas, PhD, ScD, FRCP, FMedSci c
, David A. Lomas, PhD, ScD, FRCP, FMedSci c a Division of Respiratory Medicine, Department of Medicine, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK
b Cambridge Institute for Medical Research (CIMR), University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK
c University College London, 1st Floor, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK
∗Corresponding author. Cambridge Institute for Medical Research (CIMR), University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.
Résumé |
Why only 20% of smokers develop clinically relevant chronic obstructive pulmonary disease (COPD) was a puzzle for many years. Now, epidemiologic studies point clearly toward a large heritable component. The combination of genome-wide association studies and candidate gene analysis is helping to identify those genetic variants responsible for an individual’s susceptibility to developing COPD. In this review, the current data implicating specific loci and genes in the pathogenesis of COPD are examined.
Le texte complet de cet article est disponible en PDF.Keywords : Genetics, COPD, Emphysema, GWAS, SNP
Plan
| This work was supported by the Medical Research Council (UK), British Lung Foundation, and Diabetes UK. S.J. Marciniak is an MRC Senior Clinical Fellow (G1002610). |
© 2014
Elsevier Inc. Tous droits réservés.
Vol 35 - N° 1
P. 29-38 - mars 2014 Retour au numéro
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