Cellular Adhesion and the Endothelium : E-Selectin, L-Selectin, and Pan-Selectin Inhibitors - 02/03/14
Résumé |
The pathophysiology of vasoocclusion is thought to involve a wide variety of adhesive interactions involving erythrocytes, leukocytes, and the endothelium. Selectins are expressed by leukocytes, platelets, and the endothelium, among other tissues. They contribute to a wide variety of physiologically important cell-cell interactions, including adhesion of all types of blood cells to the endothelium. In vitro, in vivo, and early-phase clinical studies suggest that E-selectin and pan-selectin inhibitors may be promising new therapeutic agents for the treatment of vasoocclusion in sickle cell disease.
Le texte complet de cet article est disponible en PDF.Keywords : Adhesion, Sickle cell disease, Endothelium, Selectins, Integrins
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| Disclosure Statement: Dr M.J. Telen has received research funding from GlycoMimetics, Inc (Gaithersburg, MD, USA) and Dilaforette, A.B (Solna, Sweden) and honoraria from Pfizer, Inc (New York, NY, USA) and Biogen Idec, Inc (Cambridge, MA, USA). |
Vol 28 - N° 2
P. 341-354 - avril 2014 Retour au numéro
Article précédent
- Cellular Adhesion and the Endothelium : P-Selectin
- Abdullah Kutlar, Stephen H. Embury
- Role of the Hemostatic System on Sickle Cell Disease Pathophysiology and Potential Therapeutics
- Zahra Pakbaz, Ted Wun
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