Total systemic ropivacaine concentrations following aerosolized intraperitoneal delivery using the AeroSurge - 05/03/14
: Postgraduate Surgical Researcher, Kah Hoong Chang, MD a : Specialist Registrar in General Surgery, Kelly Mieske, MD a : Non-Consultant Hospital Doctor, Abdelaly Abeidi, MD b : Consultant Anesthetist, Brian H. Harte, MD b, c : Consultant Anesthetist, Michael J. Kerin, MD a : Professor of Surgery, Oliver J. McAnena, MD a : Professor of Surgery, Consultant General, Upper Gastrointestinal SurgeonAbstract |
Study Objective |
To evaluate intraperitoneal ropivacaine delivery with the AeroSurge device in the clinical setting and to evaluate the total systemic ropivacaine levels achieved following delivery of 50 mg of aerosolized ropivacaine.
Design |
Preliminary, prospective, nonrandomized study.
Setting |
Operating room of a university hospital.
Patients |
5 consecutive ASA physical status 1 and 2 patients undergoing elective laparoscopic Nissen fundoplication or cholecystectomy.
Intervention |
Five mL of 1% ropivacaine was delivered through the 10 mm port using the AeroSurge device at peritoneal insufflation.
Measurements |
Venous blood samples were collected and total ropivacaine concentration was determined using liquid chromatography-mass spectrometry.
Main Results |
The AeroSurge device delivered ropivacaine, visible as mist within the peritoneal cavity. Peak concentration (Cmax) was attained between 10 and 30 minutes following the end of aerosolized ropivacaine delivery. At no stage did any level approach toxic levels.
Conclusions |
This preliminary study confirms that aerosolized intraperitoneal local anesthetic is feasible, with ropivacaine concentrations remaining within safe levels.
Le texte complet de cet article est disponible en PDF.Keywords : Anesthetics, local, Cholecystectomy, laparoscopic, Drug administration routes, Laparoscopy
Plan
| ☆ | Funding acknowledgements: AeroSurgical, Galway, Ireland, provided the device and funded biochemical analysis of the blood specimens for this study. A.M. McDermott received travel expenses (flights and accommodation) to attend the Society of American Gastrointestinal and Endoscopic Surgeons, San Diego, CA, USA, March 7–10, 2012, from AeroSurgical. AeroSurgical or employees of AeroSurgical were not involved in study design, conducting the study, or manuscript preparation. No authors were involved or related to those involved in the research or design of this device. No authors will be rewarded financially or with royalties/shares. |
Vol 26 - N° 1
P. 18-24 - février 2014 Retour au numéro
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