Increased Gastrointestinal Permeability and Gut Inflammation in Children with Functional Abdominal Pain and Irritable Bowel Syndrome - 07/03/14
, Michelle N. Eakin, PhD f, Danita I. Czyzewski, PhD a, b, c, d, Monica Jarrett, PhD g, Ching-Nan Ou, PhD a, c, d
Reprint requests: Robert J. Shulman, MD, 1100 Bates Street, Houston, TX 77030Résumé |
Objectives |
To determine gastrointestinal (GI) permeability and fecal calprotectin concentration in children 7 to 10 years of age with functional abdominal pain and irritable bowel syndrome (FAP/IBS) versus control subjects and ascertain potential relationships with pain symptoms and stooling.
Study design |
GI permeability and fecal calprotectin concentration were measured. Children kept a 2-week diary of pain episodes and stooling pattern.
Results |
Proximal GI permeability was greater in the FAP/IBS group (n = 93) compared with control subjects (n = 52) (0.59 ± 0.50 vs 0.36 ± 0.26, respectively; mean ± SD; P < .001) as was colonic permeability (1.01 ± 0.67 vs 0.81 ± 0.43, respectively; P < .05). Gastric and small intestinal permeability were similar. Fecal calprotectin concentration was greater in children with FAP/IBS compared with control children (65.5 ± 75.4 μg/g stool vs 43.2 ± 39.4, respectively; P < .01). Fecal calprotectin concentration correlated with pain interference with activities (P = .01, r2 = 0.36). There was no correlation between GI permeability and pain related symptoms. Neither permeability nor fecal calprotectin correlated with stool form.
Conclusions |
Children with FAP/IBS have evidence of increased GI permeability and low-grade GI inflammation, with the latter relating to the degree to which pain interferes with activities.
Le texte complet de cet article est disponible en PDF.Abbreviations : GI, FAP/IBS
Plan
| Supported by R01 05337 to RJS, the Daffy's Foundation, P30 DK56338 which funds the Texas Medical Center Digestive Disease Center, Daffy's Foundation, and the USDA/ARS under Cooperative Agreement No. 6250-51000-043. This work is a publication of the USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, and Texas Children's Hospital, Houston, TX. The contents of this publication do not necessarily reflect the views or policies of the USDA, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. |
Vol 153 - N° 5
P. 646-650 - novembre 2008 Retour au numéro
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