Relationships between 25-Hydroxyvitamin D Levels and Plasma Glucose and Lipid Levels in Pediatric Outpatients - 07/03/14
, Nicole S. Nader, MD b, , Amy L. Weaver, MS c, Ravinder Singh, PhD d, Seema Kumar, MD b, ⁎ 
Reprint requests: Seema Kumar, MD, Mayo Clinic, 200 First St SW, Mayo East 16 A, Rochester, MN 55905.Abstract |
Objective |
To study the relationships between serum vitamin D levels and plasma glucose or lipid levels in children and adolescents.
Study design |
We conducted a retrospective record review of pediatric outpatients (age, 2-18 years) with simultaneous measurement of 25-hydroxyvitamin D (25[OH] D) and fasting plasma glucose (n = 302) or 25(OH) D and a lipid panel (n = 177). Pearson correlation coefficient was used to estimate the correlation between 25(OH) D and logarithmic transformed plasma glucose or lipid levels. Plasma glucose and lipid levels were compared in subjects with 25(OH) D concentrations greater or less than 30 ng/mL.
Results |
25(OH) D levels were inversely correlated with fasting plasma glucose levels (r = –0.20, P < .001). Lower 25(OH) D levels were also associated with lower serum high-density lipoprotein cholesterol (HDL) concentrations (r = 0.41; P ≤ .001). The relationship between 25(OH) D levels and fasting glucose and HDL levels did not vary significantly with sex, age, body mass index z-score, or season. Children who were vitamin D insufficient (25[OH] D ≤30 ng/mL) had higher fasting plasma glucose (P = .002) and lower HDL levels (P < .001) than children who were vitamin D sufficient (25[OH] D >30 ng/mL).
Conclusions |
Low 25(OH) D levels in children and adolescents are associated with higher plasma glucose and lower HDL concentrations.
Le texte complet de cet article est disponible en PDF.Mots-clés : 25(OH) D, BMI, CV, HDL
Plan
| The authors declare no conflicts of interest. |
Vol 156 - N° 3
P. 444 - mars 2010 Retour au numéro
Article précédent
- 50 Years Ago in The Journal of Pediatrics : Testicular Feminization and Color Blindness
- Francesco De Luca
- 50 Years Ago in The Journal of Pediatrics : A Critical Evaluation of Therapy of Febrile Seizures
- Cynthia J. Campen, Paul Graham Fisher
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?