A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease - 15/03/14

Doi : 10.1016/j.gie.2013.10.027

Evan S. Dellon, MD, MPH ^1,^2,^⁎, Hannah P. Kim, MD ¹, Sarah L.W. Sperry, MD ¹, David A. Rybnicek, MD ¹, John T. Woosley, MD, PhD ³, Nicholas J. Shaheen, MD, MPH ^1,²
¹ Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
² Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
³ Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

^∗Reprint requests: Evan S. Dellon, MD, CB#7080, Bioinformatics Building, 130 Mason Farm Rd, UNC-CH, Chapel Hill, NC 27599-7080.

Abstract

Background

Phenotypes of eosinophilic esophagitis (EoE) are not well-characterized.

Objective

To describe clinical features of patients with EoE with predefined phenotypes, determine predictors of these phenotypes, and make inferences about the natural history of EoE.

Design

Retrospective study.

Setting

Tertiary-care center.

Patients

Incident EoE cases from 2001 to 2011 that met consensus diagnostic guidelines.

Intervention

Review of records.

Main Outcome Measurements

Endoscopic phenotypes, including fibrostenotic, inflammatory, or mixed. Other groups of clinical characteristics examined included atopy, level of esophageal eosinophilia, and age of symptom onset. Multinomial logistic regression assessed predictors of phenotype status.

Results

Of 379 cases of EoE identified, there were no significant phenotypic differences by atopic status or level of eosinophilia. Those with the inflammatory phenotype were more likely to be younger than those with mixed or fibrostenotic (13 vs 29 vs 39 years, respectively; P < .001) and less likely to have dysphagia, food impaction, and esophageal dilation (P < .001 for all). The mean symptom length before diagnosis was shorter for inflammatory (5 vs 8 vs 8 years; P = .02). After multivariate analysis, age and dysphagia independently predicted phenotype. The odds ratio (OR) for fibrostenosis for each 10-year increase in age was 2.1 (95% CI, 1.7-2.7). The OR for dysphagia was 7.0 (95% CI, 2.6-18.6).

Limitations

Retrospective, single-center study.

Conclusion

In this large EoE cohort, the likelihood of fibrostenotic disease increased markedly with age. For every 10-year increase in age, the odds of having a fibrostenotic EoE phenotype more than doubled. This association suggests that the natural history of EoE is a progression from an inflammatory to a fibrostenotic disease.

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Abbreviations : EoE, eos/hpf

Plan

Methods

Study design, data source, and phenotype definitions

Statistical analysis

Results

Characteristics of EoE cases

Fibrotic, inflammatory, and mixed phenotypes and phenotype predictors

Atopy, eosinophil counts, and age of disease onset

Discussion

	DISCLOSURE: This work was supported, in part, by National Institutes of Health Award K23 DK090073. No other financial relationships relevant to this publication were disclosed.
	If you would like to chat with an author of this article, you may contact Dr Dellon at edellon@med.unc.edu.
	See CME section: p. 663.