Efficiency of endocytoscopy in differentiating types of serrated polyps - 15/03/14
Abstract |
Background |
Accurate endoscopic criteria are needed to differentiate serrated polyps, including hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P), and traditional serrated adenoma (TSA), because some are precursors of colorectal cancers.
Objective |
To determine the endocytoscopic features of each type of serrated polyp, especially the shapes of lumens and nuclei.
Design |
Retrospective study.
Setting |
Single, tertiary-care referral center.
Patients |
Patients who underwent removal of serrated polyps from May 2005 to December 2012.
Intervention |
Endocytoscopy was performed. Endocytoscopic images were evaluated by assessing the shapes of the lumens and nuclei of the target lesions.
Main Outcome Measurements |
The significant endocytoscopic features in differentiating among types of serrated polyps.
Results |
Of the 58 eligible lesions, 27 were classified as HP, 12 as SSA/P, and 19 as TSA. Most HPs (77.8%) had star-like lumens, and most SSA/Ps (83.3%) had oval lumens. The lumens of TSAs were serrated (31.6%) or villous (68.4%), with both shapes seen only in TSAs. Most HPs (92.6%) and SSA/Ps (75.0%) had small, round nuclei, and all TSAs had fusiform nuclei. Features significantly differentiating TSAs from HPs and SSA/Ps were the presence of fusiform nuclei (P < .001) and villous (P < .001) and serrated (P = .002) lumens. The presence of oval lumens was significantly characteristic of SSA/Ps (P < .001), and the presence of star-like lumens was significantly characteristic of HPs (P < .001).
Limitations |
Retrospective design. Single-center study.
Conclusion |
The shape of lumens and nuclei on endocytoscopy can efficiently differentiate among the different types of serrated polyps. (Clinical trial registration number: UMIN Clinical Trials Registry UMIN000007850.)
Le texte complet de cet article est disponible en PDF.Abbreviations : CCD, HGD, HP, HR-WLE, NBI, SSA/P, TSA
Plan
| DISCLOSURE: All authors disclosed no financial relationships relevant to this publication. |
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| If you would like to chat with an author of this article, you may contact Dr Shin-ei Kudo at kudos@med.showa-u.ac.jp. |
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| See CME section: p. 663. |
Vol 79 - N° 4
P. 648-656 - avril 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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