Common White Matter Microstructure Alterations in Pediatric Motor and Attention Disorders - 16/04/14
, Frank P. MacMaster, PhD 1, 2, 3, 4, 5, 6, Susan Crawford, MSc 1, 3, 4, Catherine Lebel, PhD 2, 3, 7, Deborah Dewey, PhD 1, 2, 3, 4, 8Abstract |
Objective |
To characterize white matter alterations in children with isolated or concurrent developmental coordination disorder and/or attention-deficit/hyperactivity disorder (ADHD) compared with typically-developing controls, and to determine whether group differences on motor and attention tasks could be explained by differences in diffusion tensor imaging (DTI) measures.
Study design |
In a cohort of children (n = 85) with developmental coordination disorder, ADHD, or combined developmental coordination disorder+ADHD, we examined 3 major white matter tracts involved in attention and motor processes. Using DTI, the corpus callosum, superior longitudinal fasciculus, and cingulum were analyzed with respect to measures of white matter integrity. Differences in fractional anisotropy (FA), mean diffusivity, radial diffusivity, and axial diffusivity were analyzed using ANOVA. Motor and attentional functioning was assessed using standardized tests, and correlated to DTI measures.
Results |
FA reductions were noted in the frontal regions of the corpus callosum for children with ADHD (P = .039), whereas children with developmental coordination disorder displayed similar reductions in regions of the corpus callosum underlying parietal brain regions (P = .040), as well as the left superior longitudinal fasciculus (P = .026). White matter integrity was impacted in both frontal and parietal regions for children with comorbid developmental coordination disorder+ADHD (P = .029; .046). FA was positively correlated with scores on both motor and attentional assessments in a region-specific manner.
Conclusion |
Our findings suggest that alterations in the corpus callosum underlie difficulties in motor and attention functioning. These changes are functionally and regionally distinct and could reflect a neurobiological basis for motor and attention disorders in children.
Le texte complet de cet article est disponible en PDF.Keyword : AD, ADHD, ASF, DTI, FA, MAND, MD, MRI, NDI, RD, SLF, SPP
Plan
| ☆ | This is an open access article under the CC BY-NC-SA license (3.0/). |
| Supported by the Canadian Institutes of Health Research (MOP-86588 to D.D.), the Cuthbertson and Fischer Chair in Pediatric Mental Health (to F.M.), the Alberta Children's Hospital Foundation (F.M.), the Alberta Children's Hospital Research Institute (to L.L., D.D., F.M., C.L.), the Hotchkiss Brain Institute (to L.L., D.D., F.M., C.L.), the Mathison Center (to F.M.), and the University of Calgary. The authors declare no conflicts of interest. |
Vol 164 - N° 5
P. 1157 - mai 2014 Retour au numéro
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