A Randomized Crossover Study of Medroxyprogesterone Acetate and Diane-35 in Adolescent Girls with Polycystic Ovarian Syndrome - 12/05/14
, Alice K.W. Yiu, MBChB, MRCOG, FHKAM, FHKCOG, Tony K.H. Chung, MBBS, MD, FRANZCOG, FAMS, FHKCOG, FHKAM, FRCOG, Symphorosa S.C. Chan, MBChB, FRCOG, FHKAM, FHKCOGAbstract |
Objective |
To investigate the effects of 4-month treatment of medroxyprogesterone acetate (MPA) and Diane-35 on the clinical and biochemical features of hyperandrogenism and quality of life of adolescent girls with polycystic ovarian syndrome (PCOS).
Design |
A prospective, randomized, cross-over study.
Setting |
An accredited pediatric and adolescent gynecology clinic of a university-affiliated tertiary hospital.
Participants |
76 adolescents girls aged 14 to 19 years old with PCOS were recruited from July 2007 to July 2010.
Interventions |
Girls were randomized into 2 groups. Group 1 received oral MPA for 4 months, followed by a washout period of 4 months, and then Diane-35 for another 4 months. Group 2 received the same combination but in the reverse order.
Main Outcome Measures |
Clinical and biochemical features of hyperandrogenism and quality of life were assessed.
Results |
There was no significant difference between the 2 groups at baseline. No significant difference was found in the clinical and biochemical parameters of hyperandrogenism before and after treatment with MPA. Significant reduction of the acne score, LH/FSH ratio, and testosterone level was seen after taking Diane-35. Hirsutism was also improved but it did not reach statistical significant. When comparing post-MPA and post-Diane-35, the post-Diane-35 group had significantly improved acne score and LH/FSH ratio. No significant difference was found on quality of life between both groups after treatment.
Conclusion |
Diane-35 may be a more suitable treatment option in adolescent girls diagnosed with PCOS when compared to MPA.
Le texte complet de cet article est disponible en PDF.Key Words : Polycystic ovarian syndrome, Adolescents, Medroxyprogesterone acetate, Cyproterone acetate, Quality of life
Plan
| The authors indicate no conflicts of interest. |
Vol 27 - N° 3
P. 166-171 - juin 2014 Retour au numéro
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