Cutaneous CD30-Positive Lymphoproliferative Disorders - 28/05/14
Abstract |
Cutaneous CD30+ lymphoproliferative disorders are the second most common types of cutaneous T-cell lymphomas. They represent a well-defined spectrum encompassing lymphomatoid papulosis (LyP), primary cutaneous anaplastic large-cell lymphoma (pcALCL), and borderline lesions. They share the expression of CD30 as a common phenotypic hallmark, but they differ in their clinical presentation, course, and histologic features. New variants have been recently identified, including CD8+ epidermotropic LyP type D, angioinvasive LyP type E, and ALK-positive pcALCL. This review describes clinical, histopathologic, and phenotypic variants; their differential diagnoses (benign and malignant); and the role of CD30 as a diagnostic, prognostic, and therapeutic marker.
Le texte complet de cet article est disponible en PDF.Keywords : Lymphoma, Cutaneous, CD30, Lymphomatoid papulosis, Anaplastic large-cell lymphoma, Borderline, Clinico-pathological correlation, Systemic
Plan
| Disclosure Statement: The author has no conflicts of interest and no source of funding in the article to declare. |
Vol 7 - N° 2
P. 203-228 - juin 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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