Post-breakfast closed-loop glucose control is improved when accompanied with carbohydrate-matching bolus compared to weight-dependent bolus - 17/06/14
Abstract |
Aim |
We compared post-breakfast closed-loop glucose control either matched with a carbohydrate-matching bolus or a weight-dependent bolus.
Methods |
Twelve adults with type 1 diabetes consumed a 75g CHO breakfast on two occasions. In random order, the breakfast was accompanied by a full carbohydrate-matching insulin bolus (8.30U [7.50U–11.50U]) or a partial weight-dependent insulin bolus (0.047U/kg; 3.45U [2.95U–3.75U]). Postprandial glucose was regulated by sensor-responsive insulin and glucagon delivery.
Results |
Glucose control after the weight-dependent bolus was safe and feasible (glucose values returned to pre-prandial levels after 5h). However, 5-hr incremental area under the curve and percentage of time above 10mmol/L were lower after the full bolus compared to the partial bolus (IAUC, 2.1 [0.8–4.2]mmol/L/hr vs 8.3 [6.5–11.4] mmol/L/hr; time in hyperglycaemia, 24% [6%–29%] vs 50% [25%–63%]; P<0.001).
Conclusions |
Post-breakfast closed-loop glucose control without carbohydrate counting, but based on weight-dependent bolus is feasible but a carbohydrate-matching bolus provides better glucose control.
Clinical trial registry |
NCT01519102
Le texte complet de cet article est disponible en PDF.Keywords : Type 1 diabetes, Closed-loop delivery, Postprandial control, Glucagon, Artificial pancreas
Plan
Vol 40 - N° 3
P. 211-214 - juin 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.