A Single Misstep in Cardiac Development Explains the Co-Occurrence of Tetralogy of Fallot and Complete Atrioventricular Septal Defect in Down Syndrome - 25/06/14
Doi : 10.1016/j.jpeds.2014.02.065
Hoang H. Nguyen, MD 1, Patrick Y. Jay, MD, PhD 1, 2, ⁎ 
1 Department of Pediatrics, Washington University School of Medicine, St. Louis, MO
2 Department of Genetics, Washington University School of Medicine, St. Louis, MO
∗Reprint requests: Patrick Y. Jay, MD, PhD, Departments of Pediatrics and Genetics, Washington University School of Medicine, Box 8208, 660 South Euclid Avenue, St. Louis, MO 63110.
Abstract |
Tetralogy of Fallot and a complete atrioventricular septal defect are thought to arise by distinct mechanisms, yet their co-occurrence is a recognized association. Analysis of the prevalence of co-occurrence in Down syndrome suggests a common developmental basis. Trisomy 21 may perturb cardiac progenitor cells before they enter the heart tube.
Le texte complet de cet article est disponible en PDF.Keyword : AVSD, TOF
Plan
| P.J. is supported by an Established Investigator Award from the American Heart Association, the Lawrence J. & Florence A. DeGeorge Charitable Trust, the Children's Discovery Institute of Washington University, St. Louis Children's Hospital, the Children's Heart Foundation, the National Institutes of Health (NIH; R01 HL105857), and the Washington University Institute of Clinical and Translational Sciences (NIH National Center for Advancing Translational Sciences UL1 TR000448). The authors declare no conflicts of interest. |
© 2014
Elsevier Inc. Tous droits réservés.
Vol 165 - N° 1
P. 194-196 - juillet 2014 Retour au numéro
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