Inclusion Body Myositis - 17/07/14
, Richard J. Barohn, MD bRésumé |
The idiopathic inflammatory myopathies (IIMs) are a heterogenous group of rare disorders that share many similarities. In addition to sporadic inclusion body myositis (IBM), these include dermatomyositis, polymyositis, and autoimmune necrotizing myopathy. IBM is the most common IIM after age 50 years. Muscle histopathology shows endomysial inflammatory exudates surrounding and invading nonnecrotic muscle fibers often accompanied by rimmed vacuoles and protein deposits. It is likely that IBM has a prominent degenerative component. This article reviews the evolution of knowledge in IBM, with emphasis on recent developments in the field, and discusses ongoing clinical trials.
Le texte complet de cet article est disponible en PDF.Keywords : Inclusion body myositis, Idiopathic inflammatory myopathies, Polymyositis, Diagnosis, Pathology, Pathophysiology, Treatment, Prognosis
Plan
| This work was supported by an Institutional Clinical and Translational Science Award, NIH/National Center for Advancing Translational Sciences grant number UL1TR000001. The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. |
Vol 32 - N° 3
P. 629-646 - août 2014 Retour au numéro
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