Erythropoietin administration facilitates return of spontaneous circulation and improves survival in a pig model of cardiac arrest - 29/07/14
, Theodoros Xanthos, PhD a, b, 1, Dimitrios Barouxis, MSc a, b, Charalampos Pantazopoulos, MD a, b, Apostolos E. Papalois, PhD c, Paulos Lelovas, PhD a, Olympia Kotsilianou, MD b, Paraskevi Pliatsika, MSc a, Evaggelia Kouskouni, PhD d, Nicoletta Iacovidou, PhD b, eAbstract |
Background |
In addition to its role in the endogenous control of erythropoiesis, recombinant human erythropoietin (rh-EPO) has been shown to exert tissue protective properties in various experimental models. However, its role in the cardiac arrest (CA) setting has not yet been adequately investigated.
Aim |
The aim of this study is to examine the effect of rh-EPO in a pig model of ventricular fibrillation (VF)-induced CA.
Methods |
Ventricular fibrillation was electrically induced in 20 piglets and maintained untreated for 8 minutes before attempting resuscitation. Animals were randomized to receive rh-EPO (5000 IU/kg, erythropoietin [EPO] group, n = 10) immediately before the initiation of chest compressions or to receive 0.9% Sodium chloride solution instead (control group, n = 10).
Results |
Compared with the control, the EPO group had higher rates of return of spontaneous circulation (ROSC) (100% vs 60%, P = .011) and higher 48-hour survival (100% vs 40%, P = .001). Diastolic aortic pressure and coronary perfusion pressure during cardiopulmonary resuscitation were significantly higher in the EPO group compared with the control group. Erythropoietin-treated animals required fewer number of shocks in comparison with animals that received normal saline (P = .04). Furthermore, the neurologic alertness score was higher in the EPO group compared with that of the control group at 24 (P = .004) and 48 hours (P = .021).
Conclusion |
Administration of rh-EPO in a pig model of VF-induced CA just before reperfusion facilitates ROSC and improves survival rates as well as hemodynamic variables.
Le texte complet de cet article est disponible en PDF.Plan
| ☆ | Funding/acknowledgments: This study was funded with scholarship by the Experimental–Research Center ELPEN Pharmaceuticals (ERCE), Athens, Greece, which also kindly provided the research facilities for the project. |
Vol 32 - N° 8
P. 871-877 - août 2014 Retour au numéro
Article précédent
- Resistance of Escherichia coli urinary isolates in ED-treated patients from a community hospital
- Virginia H. Fleming, Bryan P. White, Robin Southwood
- HIV rapid testing in a Veterans Affairs hospital ED setting: a 5-year sustainability evaluation
- Herschel Knapp, Hildi Hagedorn, Henry D. Anaya
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?